A Chatbot to Support Young People During the COVID-19 Pandemic in New Zealand: Evaluation of the Real-World Rollout of an Open TrialArticle Published on 2022-11-042022-11-15 Journal: Journal of Medical Internet Research [Category] 치료제, [키워드] Adolescent mental health age Anxiety chatbot chatbots cognitive commenced Community connection COVID-19 detect dialog-based intervention digital mental health feasibility feedback flexible help highlight implementation initial iterative lockdown maintain management Mental mental health New online questionnaire open trial Positive psychology Support therapy trial infrastructure youth. [DOI] 10.2196/38743 PMC 바로가기
Hyperbaric oxygen for treatment of long COVID-19 syndrome (HOT-LoCO): protocol for a randomised, placebo-controlled, double-blind, phase II clinical trialArticle Published on 2022-11-022022-11-15 Journal: BMJ Open [Category] SARS, 진단, [키워드] approved assessment baseline Blood Cardiology case sery chronic fatigue syndrome chronic inflammation clinical clinical trial cognitive collected common COVID-19 defined domain double-blind dysfunction Effect effective Efficacy endothelial function Ethics evaluate fatigue healthy subject hyperbaric oxygen hypothese immunology IMPROVE Inconclusive independent individual initial institutional review board Long malaise mechanism monitoring board oxygen Oxygen therapy pandemic Patient peer-reviewed performed physical placebo-controlled placebo-controlled clinical trial positive Potential treatment product protocol Quality of life Questionnaires randomised rehabilitation medicine respiratory medicine (see thoracic medicine) secondary endpoint suggested survey Swedish Symptom syndrome the primary endpoint Treatment Trial VASCULAR MEDICINE. [DOI] 10.1136/bmjopen-2022-061870 PMC 바로가기
Molecular diversity and phenotypic pleiotropy of ancient genomic regulatory loci derived from human endogenous retrovirus type H (HERVH) promoter LTR7 and HERVK promoter LTR5_Hs and their contemporary impacts on pathophysiology of Modern HumansArticle Published on 2022-11-012022-11-15 Journal: Molecular genetics and genomics : MGG [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected analysis Ape apes azoospermia Brain brain regions Cancer Cell cell type cells Central nervous system cognitive Consensus conserved coronavirus COVID-19 COVID-19 pandemic database defined disorders DNA sequence dominant element embryogenesis event Evidence Evolution expressed expression fetal functional gene signature Genes genes encoding Genome genomic germline global pandemic Glutamatergic GSEA HERV HERVs Human human cell Human embryogenesis human endogenous retrovirus Human endogenous retrovirus type H (HERVH) Human endogenous retrovirus type K (HERVK) human physiology Human spermatogenesis identification Impact implicated include Infection inheritance insertion Interaction Lineage loci LTR LTR5_Hs LTR7 subfamilies majority mammalian Mammalian offspring survival genes marker Metastasis Monkey morphological feature morphologically MOS naïve neoplasm Neoplasm metastasis Neural Neuron neurons New World non-human primates observation offspring Oligospermia pathogen pathology pathophysiology Phenotypes phenotypic physiological Pleiotropy Population population-level effect primate Primate evolution promoter protein-protein interaction Protein–protein interactions at synapses proteomics Quantitative Radial rare disease recessive regulated Regulatory regulatory element regulatory sequence Release replicate representing Retrotransposition retroviral retrovirus SARS-CoV-2 SARS-CoV-2 coronavirus Schizophrenia sequence significantly Spread Stage survival synaptic Synaptic transmission Synaptic transmission. target the SARS-CoV-2 timeline traits Transmission trigeminal undergo viral genome viral infection viral infections virus viruses [DOI] 10.1007/s00438-022-01954-7 PMC 바로가기
Mental health and chest CT scores mediate the relationship between COVID-19 vaccination status and seroconversion time: A cross-sectional observational study in B.1.617.2 (Delta) infection patientsArticle Published on 2022-10-192022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome affecting analysis Analysis ANOVA B.1.617.2 B.1.617.2 Delta variant Chest computed tomography Chest CT China cognitive cognitive performance conducted coronavirus coronavirus disease Course COVID-19 COVID-19 pandemic COVID-19 vaccination cross-sectional Delta Depression effort emotional enrolled evaluated Health hospitalized patients immunization impairment Inactivated vaccine Infection Intervention Jiangsu Mediation analysis Mental mental health mitigate outbreak pandemic participant Patient patients Pearson correlation performed public health Quality Quality of life Regression analyses risk factor SARS-CoV-2 Seroconversion seroconversion time the SARS-CoV-2 vaccination Vaccination Status vaccination. variant was impaired [DOI] 10.3389/fpubh.2022.974848 PMC 바로가기
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patientsArticle Published on 2022-10-012022-11-16 Journal: The lancet. Psychiatry [Category] COVID19(2023년), SARS, 변종, [키워드] 1:1 Adults Affect age Alpha Analysis Anxiety Anxiety Disorder B.1.1.529 B.1.1.7 B.1.617.2 baseline Brain Bulgaria children cognitive Cohort cohort of patient cohorts cohorts of patient collected COVID-19 death rate Dementia Demographic factors diagnose diagnosed diagnosed with COVID-19 Diagnosis diagnosis of COVID-19 died disorder disorders Electronic health record epilepsy female Follow-up follow-up period foundation greater hazard ratio health-care health-care system help higher risk hospital HRs incidence increased risk India indicate individual Insomnia International ischaemic stroke less Malaysia male matching neurological Older other respiratory infections outcome outcomes Oxford Parkinsonism Pathogenesis Patient primary care profile proportion Psychiatric psychiatric diagnose psychiatric diagnosis psychiatric disorder reached recorded remained representing respiratory infection response retrospective cohort retrospective cohort study returned risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Seizure Seizures severe COVID-19 illness significantly Spain stratified study period sustained Taiwan trajectory USA vaccination variant variants was done while with COVID-19 Wolfson [DOI] 10.1016/S2215-0366(22)00260-7 PMC 바로가기
International PRISMA scoping review to understand mental health interventions for depression in COVID-19 patientsReview article Published on 2022-10-012022-10-05 Journal: Psychiatry research [Category] 임상, [키워드] Administered Affect article cognitive conducted COVID-19 illness COVID-19 patient COVID-19 patients COVID-19 psychological treatment database demonstrated Depression Effect Follow-up Generalizability greater indicate Intervention involved limitation Mental mental health methodology MOST muscle relaxation outcomes patients positive post-intervention primary analysis psychotherapy Randomized controlled trials Research risk scoping review searched Symptom Symptoms therapy Treatment Trial [DOI] 10.1016/j.psychres.2022.114748 [Article Type] Review article
Postvaccinal GABA-B receptor antibody encephalitis after ChAdOx1 nCoV-19 vaccinationArticle Published on 2022-10-012022-11-15 Journal: Annals of Clinical and Translational Neurology [Category] 진단, [키워드] antibody autoantibody Autoimmune AZD1222 cerebrospinal fluid ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical cognitive CSF Encephalitis GABA Immunotherapy Intravenous immunoglobulin magnetic resonance imaging male MRI occurred Patient receptor reported second dose Seizures serum treated vaccination vaccine administration [DOI] 10.1002/acn3.51659 PMC 바로가기
Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USAResearch article Published on 2022-10-012022-10-05 Journal: Brain, Behavior, & Immunity - Health [Category] 임상, [키워드] acute phase affected African American Analysis analyzed Anxiety appear average baseline Cognition cognitive Cohort Comorbidities Comorbidity Complete controls coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic demographics demonstrated Depression dysfunction Evidence Health Hypogeusia Hyposmia Infection Long COVID measure Measures mental health molecular mononuclear cell neurologic neurological Neuropsychiatric pandemic participant Patient performed physical Population positive positive COVID-19 Prospective prospective cohort study Quantitative quantitative measurement recruit recruited reported Result scored self-reported symptom Self-reported symptoms severity Socioeconomic Factors study cohort Support Symptom these symptom United State USA White patient [DOI] 10.1016/j.bbih.2022.100491 [Article Type] Research article
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disordersArticle Published on 2022-09-292022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE1 ACE2 ACE2 expression ACE2 gene addition Ageusia Alu Analysis Angiotensin-converting enzyme Anosmia association Brain Cell cells cognitive Cognitive dysfunction Cohort consequence correlation COVID-19 disorder Effect evaluated expression expression level Factors gene expression level Genetic genetic association Health Hospitalized hospitalized patients human cell initial symptoms long-COVID long-COVID syndrome Loss of Smell loss of taste molecular nasopharyngeal negative New obligatory occur Olfactory epithelium outcomes penetration polymorphism prevalent priming protease Quantitative quantitative trait receptor Regression model Research Respiratory system RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19. Spread Symptom Symptoms tissue TMPRSS2 variable virus [DOI] 10.3389/fcimb.2022.905757 PMC 바로가기
Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndromeArticle Published on 2022-09-272022-11-15 Journal: Frontiers in Endocrinology [Category] SARS, 바이오마커, [키워드] absence acute respiratory syndrome blood pressure Chronic fatigue clinical suspicion cognitive complications computed tomographic Concentration coronavirus coronavirus disease cough COVID-19 COVID-19 infection diagnosed Diagnosis diagnostic diagnostic delay Dizziness dysfunction Dyspnea fatigue had no Headaches hypertension include Infection initiated interval limit male nocturnal non-specific Other Patient patients performed pheochromocytoma pheochromocytoma (PCC) plasma plasma metanephrines Post Covid-19 preoperative recognizing resolved SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2. sweating Symptom Symptoms syndrome Thorax Tumor was performed [DOI] 10.3389/fendo.2022.967995 PMC 바로가기